Priene was an ancient ancient Greek city of Ionia at the base of an escarpment of Mycale, about 6 kilometres (3.7 mi) north of the then course of the Maeander (now called the Büyük Menderes or "Big Maeander") River, 67 kilometres (42 mi) from ancient Anthea, 15 kilometres (9.3 mi) from ancient Aneon and 25 kilometres (16 mi) from ancient Miletus. It was formerly on the sea coast, built overlooking the ocean on steep slopes and terraces extending from sea level to a height of 380 metres (1,250 ft) above sea level at the top of the escarpment. Today, after several centuries of changes in the landscape, it is an inland site. 

Priene possessed a great deal of famous Hellenistic art and architecture. The city's original position on Mount Mycale has never actually been discovered; however, it is believed that it was a peninsula possessing two harbours. Priene never held a great deal of political importance due to the city's size, as it is believed around 4 to 5 thousand inhabitants occupied the region. The city was arranged into four districts, firstly the political district which consisted of the bouleuterion and the prytaneion, the cultural district containing the theatre, the commercial where the agora was located and finally the religious district which contained sanctuaries dedicated to Zeus and Demeter and most importantly the Temple of Athena.